DOI: https://doi.org/10.9767/bcrec.20772

Recent Development in the Synthesis of 1,2,3-Triazole Derivatives Using Nanocatalysts

1School of Chemistry, Biology and Environment, Vinh University, 182 Le Duan Street, Truong Vinh, Nghean 43000, Viet Nam

2Department of Chemistry, School of Education, Vinh University, 182 Le Duan Street, Truong Vinh, Nghean 43000, Viet Nam

Received: 12 Jun 2026; Revised: 23 Aug 2026; Accepted: 26 Aug 2026; Available online: 31 Aug 2026; Published: 26 Dec 2026.
Editor(s): Istadi Istadi
Open Access Copyright (c) 2026 by Authors, Published by BCREC Publishing Group
Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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Abstract

1,2,3-Triazole is an aromatic, five-membered, π-excessive heterocycle comprised of three regular nitrogen atoms. 1,2,3-Triazoles possess a broad spectrum of bioactivities such as anticancer, antimicrobial, anti-inflammatory, antidiabetic, antiviral, and anti-HIV activity. Several compounds containing 1,2,3-triazole-moiety have been employed as drugs in the market. In organic synthesis, these heterocycles also play an important role as building blocks for different transformations. Furthermore, applications of 1,2,3-triazole derivatives as agrochemicals, corrosion retardants, polymers, optical brighteners, photostabilizers, pigments and metal chelators have also been well reported. Due to a wide range of applications, the synthesis of 1,2,3-triazoles has attracted tremendous research interest of chemists and a huge number of studies on the synthesis of these heterocycles have been published over the years. In this review article, we focus on the use of nanocatalysts for the synthesis of 1,2,3-triazoles. 70 studies on the synthesis of 1,2,3-triazoles using nanocatalyst from 2014 have been collected and analyzed. We also try to describe reaction mechanisms as much as we can. The study might be useful for chemists who work in heterocyclic synthesis or medicinal chemistry. Copyright © 2026 by Authors, Published by BCREC Publishing Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).

Keywords: Recyclability; terminal alkynes; boronic acids; click reaction; regioselectivity

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Section: Review Articles
Language : EN
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